The criteria for the diagnosis of metabolic syndrome include a large waistline (abdominal obesity), increased blood levels of the fat-type triglycerides, elevated fasting blood sugar (glucose), increased blood pressure (hypertension), and decreased levels of the “good” cholesterol HDL.
Metabolic syndrome is a multifactorial disease, which means that genetic predisposition, lifestyle, and environmental factors all interact and contribute to it. Several of the factors that contribute to the development of metabolic syndrome are modifiable, such as obesity, physical inactivity, and insulin resistance. These factors can be modified with lifestyle changes, including a healthy diet, physical activity, and weight reduction. The implementation of these health-promoting changes is particularly important due to the serious health risks associated with metabolic syndrome, especially heart disease and diabetes.
"Did you know hydrogen water has been shown to reverse metabolic syndrome?"
Healthy Sleep and Sleep Disturbances
|"Did you know hydrogen water was equivalent to caffeine at raising alertness after 24hrs of sleep deprivation"|
Sleep Deprivation and Metabolic Syndrome
Experimental Studies on the Metabolic Changes Induced by Sleep Deprivation
Experimental studies have also determined the effects of sleep deprivation on metabolism. They have demonstrated that sleep deprivation can induce metabolic risk factors, such as obesity, insulin resistance, hypertension, and dyslipidemia. Thus, it is well established that sleep deprivation increases the risk of weight gain.
Molecular Mechanisms Underlying the Relationship Between Sleep Deprivation and Metabolic Syndrome
The molecular mechanisms through which sleep deprivation induces metabolic changes are complex. Peptide hormones, inflammatory markers, catecholamines, cortisol, and the circadian rhythm have been implicated in this process.
Sleep deprivation causes changes in the levels of the peptide hormones ghrelin and leptin. Most studies have found that sleep deprivation decreases leptin and increases ghrelin levels. ¹⁸ Leptin is secreted by the adipose tissue and modulates the feeling of satiety and the balance between energy expenditure and food intake. Leptin is also known as a “satiety hormone” because it signals to the brain the feeling of satiety. ¹⁹ Ghrelin is a gut hormone known also as the “hunger hormone” because it promotes food intake, the release of growth hormone, and fat deposition.²⁰ The effects of sleep deprivation on leptin and ghrelin promote the appetite, food intake, and weight gain.
Can Healthy Sleep Habits Reverse the Negative Metabolic Consequences of Sleep Deprivation?
In another study, 3 nights of catch-up sleep managed to improve insulin resistance in patients with sleep deprivation. ²⁷
These results highlight the serious metabolic consequences associated with sleep deprivation and the importance of getting enough quality sleep. This is especially relevant because acquiring healthy sleep habits can counteract some of the negative metabolic effects of sleep deprivation for most people. However, special strategies may be necessary for shift workers or other individuals with schedules conflicting their biological clocks.⁴
Dr. Zoya Marinova is a researcher and a medical doctor with experience in the fields of translational neuroscience, epigenetics, and molecular psychiatry.