Part 1 Importance of Creatine + GAA Combo and Why It Stands Apart
January 23, 2023PART 3 Stay In Your PRIME
January 23, 2023PART 2 BUILD PRO: Push Past Plateaus and Optimize Performance
The foundation of the BUILD line is a potent performance enhancing combo that helps you push through plateaus and increase your exercise performance. BUILD PRO goes beyond BUILD + GAA, formulated to not only satisfy the requirements of a typical fitness fanatic, but also those of a professional athlete. The fact that these supplements contain components that have been demonstrated in various studies to be helpful makes them an appealing choice. From a physiological standpoint, the action mechanisms of these components are highly compatible and work together in perfect harmony. Today, BUILD PRO will be presented.
But before we continue, let’s take a brief look at some fundamental information on the standard “BUILD” formulation.
Considering creatine1:
- Improves strength
- Improves power
- Improves cognition
- Improves health
Considering guanidinoacetic acid (GAA):
- GAA improves weaker muscle groups, usually the upper body.2
- GAA can significantly improve power outputs and enhance performance.3
- GAA has antioxidant and pro-oxidant capacities.3
- GAA can enhance recovery and prevent injuries.3
- GAA increases levels of brain creatine more efficiently than any other creatine supplement. This could influence decision-making strategies and enhance alertness.4
- There is no need for a loading phase.3
- All available evidence indicates that GAA is safe to use.5
Considering BUILD:
- The results show that the GAA-creatine mixture is more effective than creatine alone for improving strength and power in muscle groups with lower initial strength levels.
- In addition, mixed GAA and creatine resulted in less weight gain than creatine administration. Creatine increases weight gain due to osmosis, and these capabilities of creatine are often considered a side effect. However, the GAA-creatine mixture appears to repeal this event.
- BUILD can be crucially important in sports with weight categories, such as combat sports. Due to GAA potential, this supplementation requires no loading period and is more effective than creatine monohydrate.
- GAA + creatine supplementation may enhance upper body muscular fitness by 25%.
- BUILD is probably the most efficient creatine-based supplement
With all of this said, let’s start with the new formulation.
BETA ALANINE
Beta-alanine (b-alanine) is a non-essential amino acid. By itself, it does not do much to make you stronger. It is made in the liver, and when it joins with L-histidine, it makes a dipeptide called carnosine.6 Carnosine acts as a buffer and makes muscles less acidic inside the cells. This is thought to be its primary job, but it may also protect cells from oxidative damage, prevent glycation, and control how sensitive cells are to calcium.7 Increased muscle carnosine levels may play an important role in exercise. Carnosine’s primary physiological role is thought to be intracellular acid-based regulation. Improving intracellular buffer capacity delays fatigue and extends exercise time.8 Intramuscular carnosine lowers muscle acidity, resulting in a lower production of hydrogen ions (H+).9 Increased H+ concentration causes a decrease in actin and myosin cross-bridge formation, resulting in a decrease in muscle contraction.10 This causes a cascade of metabolic processes, including a decrease in force production and an increase in fatigue.11 As a result, an increase in muscle carnosine may influence power performance and prolonged exercise.
There is, of course, the question of why you shouldn’t take beta-alanine instead of carnosine.
When carnosine is taken as a supplement, it is broken down before it gets to the muscles, so it cannot raise the amount of carnosine in the muscles.12 Beta-alanine supplements work best for activities that last between 1 and 4 minutes. Its effect on aerobic activities that last longer than 4 minutes is questionable, but there are some indications that it can be successful. People have different ideas about whether or not there is progress, but it has been shown that when supplementation is added to a training stimulus, performance goes up.13 Carnosine levels that are higher can also make people feel less tired, which can help them do better in sports. In strength training, it increases the amount of work done, but it does not make muscles stronger as creatine does. The amount of carnosine in muscles goes down as you get older, so older athletes and recreational participants can benefit even more.
Finally, it can be perfectly combined with creatine and GAA. Imagine you’re playing a video game, for example NBA 2K22, and you add more and more attributes to your player. Proper formulation of supplements add attributes in different areas, rather than pile on attributes that are already “maxed out”. But it is important to note that we don’t live in a world of games, and this combination is carefully planned and based on scientific evidence.
ZINC
Zinc is a mineral that plays multiple roles in our organism.The human body cannot synthesize or store zinc, making it an essential nutrient.14 That is why it is so important to incorporate it into your diet regularly. Numerous physiological functions rely on zinc, such as:14
- Strengthening of the immune system
- The enzymatic processes of gene expression
- Protein synthesis
- Repair of damaged DNA
- Wound healing
Over 300 proteins and enzymes depend on Zinc for their proper function.14 It contributes to the structural integrity of approximately 2500 transcription factors and plays a role in the control of thousands of genes. The optimum dose of Zinc depends on gender; where men should consume 11 mg per day, while women should consume 8 mg. In food, it can be found the best choices to find Zinc are red meat and fish. Therefore, Zinc is another mineral that vegetarians may find more challenging to obtain than omnivores because a plant-based diet reduces its bioavailability.15
Recognizing the relationship between zinc and physical performance requires a better knowledge of zinc intake and status in athletes and other physically active groups. There is evidence to suggest that physically active people may have a greater zinc need due to a disruption in zinc homeostasis. Zinc supplementation is only effective in relation to the quantity administered and the time it is used for. A healthy amount of Zn (10-12 mg Zn++/day) for a short length of time (1-3 month) restores immunological effectiveness and may enhance health; however long therapy or excessive doses of Zn may cause a Zn accumulation with eventual impairment to immune efficiency.16
At last, one critical zinc role is maintaining adequate testosterone levels. Research shows that there is a connection between Zinc and testosterone.17 It is well-recognized that low testosterone levels in males are linked to zinc deficiency. But, more importantly, Zinc’s involvement in the endocrine system makes it a hormone balancer by controlling testosterone levels.17 So, of course, with Zinc in your body, you will not over-increase testosterone; this will only preserve possible deficiency and keep sufficient levels of testosterone.
Optimum Zinc levels is essential for training quality and it can keep you healthy and fresh. As You can see from the figure 1. BUILD PRO contain optimum amount of Zinc ready to fulfill daily needs. BUILD PRO do not only improve your performance, but also improve your health status.
BORON
BUILD PRO is obviously a supplement that seeks to both enhance your athletic performance and protect your health. Even though we are told that sports and exercise are good for us, doing too much of either can have serious consequences. Increased inflammation may result from training that was improperly dosed. It is well-known that an athlete’s immunity is at its weakest right after a game or intense training. Consequently, everyone who works out should prioritize their health above all else.
Boron (B) is unlike any other element in the periodic table. It is the sole nonmetal in Group 13 of the Mendeleev Periodic Table, and it has many of the same properties as carbon and diagonal relative silicon. It is abundant in nature and is always found coupled to oxygen.18 Boron concentrations of about 0.001% can be found in deposits in the earth’s crust (10 ppm). Its concentration in saltwater is typically measured at 4.6 parts per million (range, 0.5 to 9.6 ppm). Boron is only obtained in the form of compounds, never in its elemental condition.19 A survey conducted in the United States between 1994 and 1996 found that the adult’s boron intake was between 0.35 to 3.25 milligrams per day (mg/day). On average, adults consumed 0.87 to 1.13 mg/day of Boron.20 Recommended dose of Boron ranges between 1-3 mg/day.
Reduced brain function, impaired inflammation control, impaired immune response, and an increased risk of some cancers have all been related to a lack of boron in the diet.18 However, there is little evidence to show that supplemental boron levels above those obtained through a regular diet are beneficial. Therefore, supplementation is likely to be helpful only when food consumption is insufficient. In addition, boron has been investigated for its function in bone and joint health, dysmenorrhea, and radiation dermatitis. Therefore, 1mg of Boron additionally will fulfill daily doses of Boron, and improve cellular health.
There is evidence, same as in case with Zinc, that Boron supplementation will keep testosterone production at healthy and optimal levels. 21 So adding these components will for sure keep your engine in balance. Zinc and Boron are primarily used to prevent deficiencies and guarantee that testosterone production is sustained.
BUILD PRO is a powerful formulation created to maximize physical performance in exercise, preserve a healthy mineral balance, and enhance the body’s defenses against illness. Take a BUILD PRO if you need an energy boost, want to bulk up, and value your physical and mental well-being.
REFERENCE
- Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., … & Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14(1), 18.
- Semeredi, S., Stajer, V., Ostojic, J., Vranes, M., & Ostojic, S. M. (2019). Guanidinoacetic acid with creatine compared with creatine alone for tissue creatine content, hyperhomocysteinemia, and exercise performance: A randomized, double-blind superiority trial. Nutrition, 57, 162-166.
- Ostojic, S. M. (2015). Advanced physiological roles of guanidinoacetic acid. European journal of nutrition, 54(8), 1211-1215.
- Ostojic, S. M., Ostojic, J., Drid, P., & Vranes, M. (2016). Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men. Applied Physiology, Nutrition, and Metabolism, 41(9), 1005-1007.
- Ostojic, S. M. (2021). Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy?. Nutrients, 14(1), 75.
- Varanoske, A. N., Stout, J. R., & Hoffman, J. R. (2019). Effects of β-alanine supplementation and intramuscular carnosine content on exercise performance and health. In Nutrition and enhanced sports performance (pp. 327-344). Academic Press.
- Boldyrev, A. A., Aldini, G., & Derave, W. (2013). Physiology and pathophysiology of carnosine. Physiological reviews.
- Hobson, R. M., Saunders, B., Ball, G., Harris, R. C., & Sale, C. (2012). Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino acids, 43(1), 25-37.
- Cady, E. B., Jones, D. A., Lynn, J., & Newham, D. J. (1989). Changes in force and intracellular metabolites during fatigue of human skeletal muscle. The Journal of physiology, 418(1), 311-325.
- Fabiato, A., & Fabiato, F. (1978). Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles. The Journal of physiology, 276(1), 233-255.
- Dutka, T. L., & Lamb, G. D. (2004). Effect of carnosine on excitation–contraction coupling in mechanically-skinned rat skeletal muscle. Journal of Muscle Research & Cell Motility, 25(3), 203-213.
- Gardner, M. L., Illingworth, K. M., Kelleher, J. E. R. R. Y., & Wood, D. I. A. N. A. (1991). Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose. The Journal of physiology, 439(1), 411-422.
- Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., Hoffman, J. R., Wilborn, C. D., Sale, C., … & Antonio, J. (2015). International society of sports nutrition position stand: Beta-Alanine. Journal of the International Society of Sports Nutrition, 12(1), 30.
- Tudor, R., Zalewski, P. D., & Ratnaike, R. N. (2005). Zinc in health and chronic disease. The journal of nutrition, health & aging, 9(1), 45-51.
- Hunt, J. R. (2003). Bioavailability of iron, zinc, and other trace minerals from vegetarian diets. The American journal of clinical nutrition, 78(3), 633S-639S.
- Mocchegiani, E., & Malavolta, M. (2009). Role of zinc and selenium in oxidative stress and immunosenescence: implications for healthy ageing and longevity. In Handbook on immunosenescence (pp. 1367-1396). Springer, Dordrecht.
- Prasad, A. S., Mantzoros, C. S., Beck, F. W., Hess, J. W., & Brewer, G. J. (1996). Zinc status and serum testosterone levels of healthy adults. Nutrition, 12(5), 344-348.
- Khaliq, H., Juming, Z., & Ke-Mei, P. (2018). The physiological role of boron on health. Biological trace element research, 186(1), 31-51.
- White, M. A., Cerqueira, A. B., Whitman, C. A., Johnson, M. B., & Ogitsu, T. (2015). Determination of phase stability of elemental boron. Angewandte Chemie, 127(12), 3697-3700.
- Russell, R., Beard, J. L., Cousins, R. J., Dunn, J. T., Ferland, G., Hambidge, K., … & Yates, A. A. (2001). Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. A report of the panel on micronutrients, subcommittees on upper reference levels of nutrients and of interpretation and uses of dietary reference intakes, and the standing committee on the scientific evaluation of dietary reference intakes food and nutrition board Institute of medicine, 797.
Pizzorno, L. (2015). Nothing boring about boron. Integrative Medicine: A Clinician’s Journal, 14(4), 35.